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Stilnox (Zolpidem): An Overview

Stilnox, also known by its generic name zolpidem, is a prescription medication classified as a non-benzodiazepine sedative-hypnotic. It is primarily prescribed for the short-term treatment of insomnia, characterized by difficulty falling asleep or staying asleep. Stilnox works by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that helps to induce sleep and reduce wakefulness.

Indications for Stilnox Use:

Stilnox is indicated for the short-term management of insomnia, including difficulty falling asleep and/or maintaining sleep. It is used when insomnia is severe, disabling, or causing significant distress to the individual. Stilnox is typically prescribed for short-term use, generally for 7 to 10 days, to minimize the risk of dependence and tolerance.

Administration Method and Dosage:

Stilnox is available in various formulations, including immediate-release tablets and extended-release tablets. The dosage of Stilnox varies depending on the individual's age, medical condition, and response to treatment. It is typically administered orally, just before bedtime, with a full glass of water. The recommended starting dose for adults is 5 mg for immediate-release tablets and 6.25 mg for extended-release tablets. The dosage may be adjusted based on individual response and tolerability, but it should not exceed 10 mg per day for immediate-release tablets and 12.5 mg per day for extended-release tablets.


After oral administration, Stilnox is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1 to 2 hours for immediate-release tablets and within 1.5 to 2.7 hours for extended-release tablets. The drug undergoes extensive metabolism in the liver by the cytochrome P450 enzyme system, primarily to inactive metabolites. The elimination half-life of Stilnox is approximately 2.5 to 3 hours for immediate-release tablets and 6.5 to 8.7 hours for extended-release tablets. The drug and its metabolites are primarily eliminated from the body through renal excretion.

Features of Use:

Stilnox should be used cautiously in patients with a history of substance abuse, as it has the potential for misuse, dependence, and addiction. It should be used with caution in elderly patients and individuals with liver or kidney impairment, as they may be more sensitive to the effects of the drug. Abrupt discontinuation of Stilnox after prolonged use may result in withdrawal symptoms, including rebound insomnia, anxiety, agitation, and tremors. Therefore, Stilnox should be tapered gradually under the supervision of a healthcare provider to minimize the risk of withdrawal reactions.

Interaction with Other Medicinal Products:
Stilnox may interact with other medications, including other central nervous system depressants such as alcohol, opioids, and sedative-hypnotics, leading to additive effects and increased risk of respiratory depression, sedation, and coma. It may also interact with certain medications that inhibit or induce the cytochrome P450 enzyme system, affecting the metabolism and clearance of Stilnox from the body. Therefore, it is important to inform healthcare providers about all medications, supplements, and herbal products being taken to avoid potential drug interactions.

Side Effects:
Common side effects of Stilnox include drowsiness, dizziness, lightheadedness, fatigue, headache, and gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea). These side effects are usually mild and transient, but they may persist or worsen with continued use. Less common but more serious side effects include memory impairment, sleepwalking, sleep-related behaviors (e.g., driving, eating), and dependence or addiction with long-term use. Patients experiencing any concerning side effects should seek medical attention promptly.Picture Gallery

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